 |
|
 |
- May 17, 2008 |
|
|
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.
CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
|
|
|
| Presentation |
|
"What is the evidence for combination therapy with a TZD added to metformin or a sulfonylurea?"Dr. Julio Rosenstock (biography)
English - 2004-06-04 - 21 minutes
|
 | (12 slides) |
Summary :
Combination therapy for type 2 diabetes should achieve a durable effect as well as targeting the dual defects of insulin resistance and beta cell dysfunction.
The insulin-sensitizing effects of glitazones result in less strain on the pancreatic beta cell. When combined with submaximal doses of metformin or sulfonylurea (SU), combination therapy with TZDs has been shown to provide a sustained and more robust glucose-lowering effect.
The TZD/metformin combination has a powerful effect on reducing insulin resistance and is effective in the early stages of type 2 diabetes when more endogenous insulin is still available. This combination is also associated with minimal hypoglycaemia and less weight gain. The SU/TZD combination offers the added benefit of lowered insulin resistance and improvement in beta cell function.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
After viewing these slides the participant will be able to discuss:
- The advantages of adding a TZD to metformin or SU monotherapy
Bibliographic references :
Daniel Einhorn MD, Marc Rendell MD, James Rosenzweig MD, John W. Egand, Annette L. Mathisen PhD, Roberta L. Schneider MD and The Pioglitazone 027 Study Group. Pioglitazone hydrochloride in combination with metformin in the treatment of type 2 diabetes mellitus: A randomized, placebo-controlled study Clinical Therapeutics.2000;22(12):1395-1409.
|
|
|
|
|
|
| Search our website |
 |
| |
Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes. |
| |
|
|
| Social |
|
| |
Let others know about this presentation.
|
|
|
|
