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- May 11, 2008 |
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"Usefulness of Brachial Artery Distensibility in the Prediction of Coronary Risk Among Asymptomatic Individuals With and Without Metabolic Syndrome"Dr. Meng Cheng Chiang (biography)
English - 2005-04-16 - 21 minutes
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Summary :
Objective: Previous studies have shown that brachial arterial distensibility (BD) is a measure of arterial stiffness and may be used in risk assessment for cardiovascular disease (CVD). The aim of this study is to explore the predictive value of BD for CVD risk level in asymptomatic individuals with and without Metabolic Syndrome and to seek cardiovascular risk factors influencing BD.
Study design: In this study, BD data were obtained using the DynaPulse 2000A instrument (Pulse Metric, Inc, USA) in 281 asymptomatic, apparently healthy subjects (M/F= 143/138; aged 51(+/-)13 years) who were admitted for routine physical check-ups. Family history, serum lipids and lipoproteins, glucose levels and mercury sphygmomanometer blood pressure measurements were obtained. The risk for CVD in each individual was assessed using the Framingham Risk Score system.
Results: Significant correlations were found between unadjusted BD and age, gender, measures of blood pressure, and heart rates. There was a significantly negative correlation between BD and the Framingham risk scores (r = -0.414, P <0.0001). Subjects with metabolic syndrome had significantly lower BD than those who without metabolic syndrome (5.5(+/-)1.0 %/mmHg vs. 6.0(+/-)1.3 %/mmHg, P= 0.0126). A multiple linear regression analysis showed that BD was an independent predictor of a 10-year risk for future coronary heart disease events.
Conclusion: These findings indicate that non-invasive measures of BD are useful in measuring sub-clinical vascular changes and are effective in assessing CVD risk in persons both with and without metabolic syndrome.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- The relationship between brachial artery distensibility and cardiovascular risk
- CV risk factors influencing brachial artery distensibility
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