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- May 16, 2008 |
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"The VICTORY Study: Assessing the efficacy of rosiglitazone in inhibiting the progression of atherosclerosis in CABG surgery" (biography)
English - 2005-10-25 - 29 minutes
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Summary :
In this talk Dr. Bertrand gives an overview of the design and objectives of the VICTORY (VeIn-Coronary ATherOsclerosis and Rosiglitazone after Bypass surgerY) trial.
Research conducted at the Montreal Heart Institute on bypass patients has shown that the majority of vein grafts show atherosclerotic changes after 10 years. The overall objectives of VICTORY are to assess the efficacy of rosiglitazone to reduce the progression of atherosclerosis in vein grafts and native coronary arteries in diabetic patients after coronary bypass surgery, as well as to assess the efficacy of rosiglitazone to improve metabolic parameters in these patients. The primary endpoint is the change in plaque volume over 12 months in a segment of at least 40mm in one vein graft, as measured by IVUS.
Dr. Bertrand describes the study design further and presents data obtained from the first patient included in the study, showing the changes from baseline to one year as measured by IVUS, CT-scan and DEXA.
Copyright © 2005 E-MedHosting.com Inc.
Learning objectives :
Key learning points:
1. Presentation of the VICTORY trial protocol, the first cardio-metabolic trial in type 2 diabetes patients to assess atherosclerosis progression and its detailed interrelations with metabolic abnormalities.
2. Understand the combinations of intravascular ultrasound, angiography, DEXA, abdominal CT-scan, exercise test, holter monitoring and biological markers to assess cardio-metabolic abnormalities in type 2 diabetes patients.
3. Understand the use of saphenous vein graft as a clinical model of accelerated atherosclerosis.
4. Understand the use of DEXA and abdominal CT-scan to assess morphology abnormalities in type 2 diabetes patients.
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