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- August 7, 2008 |
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CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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"The Acute Effect of Various Glycemic Index Dietary Carbohydrates"Dr. Talya Lavi (biography)
English - 2005-04-15 - 24 minutes
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Summary :
Postprandial hyperglycemia is as an important risk factor for cardiovascular disease. The current study was designed to explore the acute effect of various glycemic index dietary carbohydrates on endothelial function.
Methods: We prospectively assessed endothelium-dependent flow-mediated vasodilation (FMD) brachial artery vasoreactivity non-invasively in 34 consecutive healthy non-diabetic volunteers [26 normoglycemic (NGT) and 8 impaired glucose tolerance (IGT)] without known CVD. All subjects were studied on 4 separate mornings, 1-2 weeks apart. At each visit, after an overnight fast and discontinuation of all medications for ≥12 hours, FMD and (NTG) were assessed, using high resolution linear array ultrasound. Subjects randomly received one of 3 carbohydrate-based meals, each with a different glycemic index (glucose, cornflakes, fiber) or placebo (water). Two hours postprandial a repeat endothelial function test was performed.
Results: . Fasting blood glucose and post 75g glucose- bg and triglycerides were significantly higher in the IGT Baseline %FMD was not significantly different in all 3 carbohydrate-based and placebo meals in both study groups. However, it was significantly reduced 2 hours postprandial in the glucose-base and cornflakes meals (Figure), which have higher glycemic index then the fiber.
Conclusion: Carbohydrate meals with high glycemic index suppress endothelial function in the brachial artery in NGT and IGT subjects, suggesting a mechanism whereby high glycemic index..
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- The effect of oral glucose loading on endothelial function
- The effect of different glycemic index foods on endothelial function
Bibliographic references :
Hiroaki Kawano MD, Takeshi Motoyama MD, Osamu Hirashima MD, Nobutaka Hirai MD, Yuji Miyao MD, Tomohiro Sakamoto MD, Kiyotaka Kugiyama MD, Hisao Ogawa MD and Hirofumi Yasue MDHyperglycemia rapidly suppresses flow-mediated endothelium- dependent vasodilation of brachial arteryJournal of the American College of Cardiology
Volume 34, Issue 1 , July 1999, Pages 146-154.
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