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Prof. Thomas A. Buchanan
Education
High School
Grundy Community High School, Grundy Center, IA, 1971
University
Iowa State University, B.S., 1975.
Medical School
University of Iowa, M.D., 1978
Residency
Good Samaritan Hospital, Phoenix, AZ, 1978-80
University of Iowa Hospital, Iowa City, IA, 1980-81
Fellowship
Northwestern University Medical School, 1981-84,
Endocrinology and Metabolism (Preceptor: Norbert Freinkel)
Honors
Phi Beta Kappa, Iowa State University, 1974
Top Graduating Scholar, College of Sciences and Humanities, Iowa State University, 1975
High Scholarship Student, Iowa State University, 1975
Taylor Scholarship, University of Iowa College of Medicine, 1975
Alpha Omega Alpha, University of Iowa, 1978
Individual National Research Service Award, NIH (1982-84)
Young Investigator Research Award, American Diabetes Association (Northern Illinois Affiliate), 1983, 1985
Clinical Research Fellowship, Chicago Community Trust, 1984
Novo-Nordisk International Lecture, Canadian Diabetes Assn, 1995
Medisense International Lecture, Australian Diabetes Assn, 1995
Norbert Freinkel Award, American Diabetes Association, 1999
John Ensinck Lecture, University of Washington, 2000
Board Certification
American Board of Internal Medicine, 1981
Subspecialty: Endocrinology and Metabolism, 1983
Professional Background
Academic Appointments
Instructor in Medicine, Northwestern University Medical School, 1984-85
Assistant Professor of Medicine, Northwestern University Medical School, 1985-86
Assistant Professor of Medicine, University of Southern California School of Medicine, 1986-92
Associate Professor of Medicine and Obstetrics and Gynecology (Tenured), University of Southern California School of Medicine, 1992-99
Professor of Medicine, Obstetrics and Gynecology, and Physiology and Biophysics, University of Southern California Keck School of Medicine, 1999-present
Teaching Responsibilities
Year II Pathophysiology, USC School of Medicine:
Lecturer, 1987-present
Coordinator, Diabetes Section, 1989-92.
Chairman, Endocrine Organ System, 1993-94
Year I Physiology, USC School of Medicine: Diabetes Clinical Correlates, 1988-94
Department of Medicine, Division of Endocrinology and Diabetes, LAC+USC Medical Center
Clinical Teaching, Diabetes and Medicine Inpatient Services, 1986-present
Clinical Teaching, Diabetes and Pregnancy Outpatient Clinics, 1986-95
General Clinical Research Center, USC School of Medicine:
Course Development and Director: "Methods in Clinical Investigation", 1994-present
Administrative Responsibilities and Intramural Committees
General Clinical Research Center, USC School of Medicine:
Member, Advisory Committee, 1992-93
Director, Training Program in Clinical Investigation, 1993-present
Associate Program Director, 1993-96
Program Director, 1996-present
Division of Endocrinology and Diabetes, LAC+USC Medical Center:
Director of Fellowship Training, 1992-98
Radiation Safety Committee, USC Health Sciences Campus: Member, 1991-94
Year 2 Medial Student Curriculum Committee, USC School of Medicine: Member, 1993-94
Institutional Animal Care and Use Committee, USC: Member, 1993-95
Institutional Review Board, USC and LAC+USC Medical Center: Member 1996-present
M.D./Ph.D. Committee, USC School of Medicine: Member, 1999 -present
Executive Research Compliance Committee, USC: Member, 2000-Present
Task Force on Faculty Rights and Obligations in Research Compliance, USC Academic Senate:
Member, 2000-2002
Research Committee, USC Academic Senate: Member, 2000
Peer Review Activities
Editorial Boards
American Journal of Physiology: Endocrinology and Metabolism, 1998-2001
Clinical Diabetes: 2000-2001
Grant Review
National Institutes of Health
Site Visitor, NIH/NCRR/GCRC, 12/93
Member, Ad Hoc IRG, NIH (NIDDK) RFA: Prevention of NIDDM, 4/94
Chair, Ad Hoc IRG, NIH (NIDDK): Hyperglycemia and Perinatal Outcome; 1995, 1997, 1998.
Member, Ad Hoc IRG, K-30 Clinical Research Training Awards, 1999
Veterans Administration
Member, VA Merit Review Committee in Endocrinology, 1996-2000
American Diabetes Association
Member, California Research Grant Review Committee, 1990
Member, National Research Grant Review Panel, 1996-99
American Heart Association
Member, Research Grant Review Committee, Los Angeles Affiliate, 1994-95
Extramural Committees
American Diabetes Association - National
Council on Diabetes in Pregnancy
Secretary, 1992-94
Program Chair, 1994 and 1996
Vice Chair, 1994-96
Chair, 1996-98
Professional Section Advisory Panel, Member, 1996-98
Publications Policy Committee Member, 1998-1999, 2000-2001
Professional Practice Committee, Member, 2000-02
President, Western Region: 2000-2001
Board of Directors, Member, 2001-2004
Research Policy Committee, Member 2002-2004
American Diabetes Association - California Affiliate
Scientific and Professional Education Committee, Member, 1992-96
American Federation for Medical Research
Councilor-at-Large, 2002-
CDC Task Force on Birth Defects in Diabetes
Member, 1992-1994
Endocrine Society
Chair, Diabetes Section, Clinical Endocrine Updates 2000
General Clinical Research Centers Program Directors' Association
Member, Executive Committee, 1998-2001
President-Elect, 1999-2000
President, 2000-2001
International Association of Diabetes and Pregnancy Study Groups
Member, Executive Committee, 1998 - present
Chair, Scientific Program Committee, 1998 meeting
Chair, Scientific Program Committee, 2003 meeting
International Workshop-Conferences on Gestational Diabetes Mellitus:
Summary Committee on Screening and Diagnosis, 3rd Workshop, Member, 1990.
Planning Committee, 4th Workshop, Member, 1997
Summary Committee on Therapeutic Options, 4th Workshop, Chair, 1997
NIH Congressionally Established Diabetes Research Working Group:
Subcommittee on Women's and Children's Issues, Member, 1998-99
National Center for Research Resources, NIH
Director's Advisory Committee on Clinical Research: Member, 2000-
Working Group on Industry-Sponsored Research: Member, 2000-2001
West Coast Metabolism Club:
Chair, 1991-92
Western Society for Clinical Investigation:
Council Member, 2001-2004
Chair, Metabolism Abstract Committee, 2002-2003
Society Memberships
Local and Regional
American Diabetes Association, California Affiliate
American Diabetes Association, Los Angeles Chapter
American Federation for Medical Research, Western Region
Western Society for Clinical Investigation
Diabetes in Pregnancy Study Group - West (Charter Member)
National/International
American Diabetes Association
American Federation for Medical Research
International Diabetes Federation
European Assn. for the Study of Diabetes
The Endocrine Society
High Blood Pressure Council, AHA
Diabetes in Pregnancy Study Group, EASD
National, International and Named Lectures
"Diabetes in Pregnancy". Endocrine Society Postgraduate Assembly, October 1989
"Insulin Resistance and Hypertension". NIH Visiting Scientist, Paulista University, Sao Paulo, Brazil, September 1990
"Insulin Resistance in Pregnancy". Plenary Lecture, Satellite to the 14th International Diabetes Federation Congress, Newport RI, June 1991
"Management of the Pregnant Diabetic Patient". Endocrine Society Postgraduate Assembly, October 1991
"Insulin Resistance in Pregnancy". Invited Lecture, 1st International Symposium on Diabetes and Pregnancy in the 90's. Tel Aviv, Israel, March 1992
"Gestational Diabetes and Non-Insulin-Dependent Diabetes". Invited Lecture, International Symposium on Gestational Diabetes. Graz, Austria, October 1992
"Insulin Action and Secretion in Pregnancy and GDM". Keynote Address, European Diabetes in Pregnancy Study Group Annual Meeting, 1993
"Effects of Glycemia on Embryogenesis". Invited Lecture, Universidad de Calcala, Madrid, Spain. March, 1993
"GDM and NIDDM: What's the Link?". Special Research Seminar, University of Padua, Italy, September, 1994
"Fetal Growth in Diabetic Pregnancies". Symposium Lecture, 15th International Diabetes Federation Congress, Kobe, Japan. November, 1994
"Diabetic Microangiopathy in Pregnancy". Symposium Lecture, 15th International Diabetes Federation Congress, Kobe, Japan. November, 1994
"Pathogenesis of Gestational Diabetes: Pancreatic B-cell Function". Keynote Lecture, 2nd International Symposium on Diabetes and Pregnancy, Jerusalem, March, 1995
"Gestational Diabetes: May Logic Prevail". Novo-Nordisk International Lecture, Canadian Diabetes Association Annual Scientific Meeting, September, 1995
"Treatment of Gestational Diabetes Using Fetal Criteria". Medisense International Lecturer, Australian Diabetes in Pregnancy Society Annual Meeting. September, 1995
"Birth Defects in Diabetic Pregnancies". Medisense International Lecturer, Australian Diabetes Society Annual Meeting, September, 1995
"Pathophysiology of Gestational Diabetes". Keynote Lecture, Special Symposium on Diabetes in Pregnancy, Swedish Medical Society, Stockholm, Sweden, November, 1995
"Diabetes and Pregnancy". Symposium Lecture, National Medical Association, Chicago, July, 1996
"Fetal Criteria in The Management of GDM". Symposium Lecture, 4th International Workshop-Conference on GDM, Chicago, March, 1997
"Fuel-Mediated Teratogenesis". Frontiers in Diabetology, Steno Memorial Hospital, Copenhagen, Denmark, May, 1997.
"Treatment of Gestational Diabetes". Frontiers in Diabetology, Steno Memorial Hospital, Copenhagen, Denmark, May, 1997.
"Prediction and Prevention of Diabetes after Gestational Diabetes". Symposium Lecture, 16th International Diabetes Federation Congress, Helsinki, Finland, July, 1997
"Prediction and Prevention of Diabetes after Gestational Diabetes". Keynote Lecture, Brazilian Diabetes Association Annual Meeting, Porto Alegre, Brazil, September, 1997
"New Strategies for Management of Gestational Diabetes during Pregnancy". Keynote Lecture, Brazilian Diabetes Association Annual Meeting, Porto Alegre, Brazil, September, 1997
"Prediction and Prevention of Diabetes after GDM". Colombian Society of Obstetrics and Gyencology Annual Meeting, Cali, Colombia, March, 1998.
"New Concepts in Antepartum Management of Gestational Diabetes". Colombian Society of Obstetrics and Gyencology Annual Meeting, Cali, Colombia, March, 1998.
"Prevention of Birth Defects in Diabetic Pregnancies". Colombian Society of Obstetrics and Gynecology Annual Meeting, Cali, Colombia, March, 1998.
"Pancreatic B-cell Function in Women at High Risk for Type 2 Diabetes". Symposium Lecture, American Diabetes Association National Meeting, June, 1998.
"Ultrasound in the Management of Gestational Diabetes". Symposium Lecture, American Diabetes Association National Meeting, June, 1998.
"Future Risks of New GDM, Diabetes and IGT". Symposium lecture, Barcelona '98 Conference on Gestational Diabetes, Barcelona, Spain, September, 1998.
"Pathophysiology of Gestational Diabetes". Symposium lecture, Barcelona '98 Conference on Gestational Diabetes, Barcelona, Spain, September, 1998.
"New Concepts in the Management of Gestational Diabetes". Keynote Lecture, Argentine Diabetes Association Meeting, Cordoba City, Argentina, October, 1998.
"Predicting and Preventing Diabetes after Gestational Diabetes". Keynote Lecture, Argentine Diabetes Association Meeting, Cordoba City, Argentina, October, 1998.
"Diabetes in Hispanic Americans: Prevention as the Ultimate Cure". Symposium Lecture, Endocrine Society Annual Meeting, San Diego, CA, June, 1999.
"Risk Stratification in Gestational Diabetes: Sorting Wheat from Chaf". Norbert Freinkel Lecture, American Diabetes Association Annual Meeting, San Diego, CA, June, 1999.
"Measuring Insulin Sensitivity in Pregnancy". Meet the Professor Session. American Diabetes Association Annual Meeting, San Diego, CA, June, 1999.
"Prevention of Type 2 Diabetes: Lessons from Gestational Diabetes. Keynote Address, Portuguese Diabetes Association, Madiera, Portugal, February, 2000
"Prevention of Type 2 Diabetes after Gestational Diabetes". Keynote Lecture, Diabetes in Pregnancy Study Group of EASD, Tiberias, Isreal, September, 2000
"Diabetes and Pregnancy: What Internists Need to Know", John Ensign Lecture, University of Washington, Seattle, WA, October, 2000
"Type 2 Diabetes: An Ounce of Prevention and a Pound of Cure", International Society for Pediatric and Adolescent Diabetes, Los Angeles, CA, November, 2000
"Diabetes Prevention: Lessons from Gestational Diabetes", International Diabetes Epidemiology Group, Acapulco, Mexico, November, 2000
"Prevention of Type 2 Diabetes", International Diabetes Federation Meeting, Mexico City, November, 2000
"Prevention of Type 2 Diabetes by Reducing Secretory Demands on B-cells", Symposium Lecture, Endocrine Society, June, 2001
"Prevention of Type 2 Diabetes by Reducing Secretory Demands on B-cells", Symposium Lecture, American Diabetes Association Annual Scientific Sessions, June, 2001
"Preventing Type 2 Diabetes by Treating Insulin Resistance". Symposium Lecture, European Association for the Study of Diabetes Annual Meeting, September 2001
"Preventing Type 2 Diabetes after Gestational Diabetes". Invited lecture, European Diabetes in Pregnancy Study Group, September 2001
"Controversies in Gestational Diabetes". Plenary lecture, German Diabetes Association, May 2002
"Preventing Type 2 Diabetes". Symposium Lecture, American Diabetes Association Annual Scientific Sessions, June 2002 Research Activities
Major Areas of Research Interest
Pathogenesis, genetics and prevention of type 2 diabetes
Metabolic influences on intrauterine growth and development
Insulin resistance and blood pressure regulation
Research in Progress
Insulin action and B-cell function in gestational and type 2 diabetes
Prevention of type 2 diabetes in women with prior gestational diabetes
Genetics of pancreatic B-cell failure in type 2 diabetes
Use of fetal parameters to guide treatment of gestational diabetes
Physiology and genetics of insulin action and salt sensitivity of blood pressure
Active Grants (T. Buchanan, P.I. unless otherwise indicated)
1. Pathogenesis of Type 2 Diabetes in Latino Women. Source: NIDDK/NIH (R01 DK46374); Project dates: 7/1/98-6/30/03; 5-year direct costs: $1,407,139.
2. General Clinical Research Center (PI: Van Der Meulen; Program Director: Buchanan).
Source: NCRR/NIH (M01 RR00043). Project Dates: 12/1/97-11/30/02. 5-year Direct Costs: $29,658,797.
3. Pioglitazone in Women with Prior Gestational Diabetes. Source: Takeda Pharmaceuticals America; Project Dates: 9/1/00 - 2/31/05; 5-year direct costs: $1,444,205. (INVESTIGATOR INITIATED, DESIGNED and CONDUCTED).
Pending Grants
1. Genetics of Beta Cell Failure in Mexican Americans. Source: NIH/NIDDK; Project Dates 8/1/02 - 7/31/07; 5-year direct costs: $4,781,673 (9th percentile; NOGA pending)
Prior Grants (T. Buchanan, P.I. unless otherwise indicated)
1. Effects of Maternal Insulin-induced Hypoglycemia on Embryogenesis in the Rat. Feasibility Grant, American Diabetes Association. 7/1/86 - 6/30/89. $50,000.
2. Inquiries into the Mechanism of the Teratogenic Effect of Maternal Insulin-Induced Hypoglycemia in an Animal Model. Research Grant, Juvenile Diabetes Foundation. 9/1/87 - 8/31/89. $72,000
3. The Physiological Significance of the Hypothermic Response to Hypoglycemia. Research Grant, American Diabetes Association (CA Affiliate). 7/1/88 - 6/30/89. $35,000
4. Development of a New Technique to Measure Hepatic Glucose production In Vivo. Research Grant, Diabetes Research and Education Foundation. 7/1/89 - 6/30/90. $18,000.
5. Insulin Therapy in Class A1 Gestational Diabetes: Effects on Maternal Metabolism and Fetal Development. Clinical Research Award, American Diabetes Association. 7/1/89-6/30/92. $150,000.
6. Insulin Sensitivity in Experimental Hypertension. Grant-in-Aid, American Heart Association. 7/1/90-6/30/93. $90,000.
7. Hypertension in Obesity and Diabetes Mellitus. Source: NIH (P50-HL-44404; Project 1). W. Hsueh, PI; (T. Buchanan, Co-PI). Dates: 12/90 to 11/95. Direct Costs: $1,163,429
8. Effect of Hypertension on Insulin Action. NIH (P50-HL-44404; Project 9). R. Bergman, PI; (T. Buchanan, Co-PI). Dates: 12/90 to 11/95. Direct Costs: $735,673
Prior Grants (cont'd)
9. Pharmacodynamic Response of GG747 in the Frequently Sampled Intravenous Glucose Tolerance Test. Source: Glaxo Pharmaceuticals. Richard N. Bergman, PI. (T. Buchanan, Co-PI). Dates: 6/1/94 to 9/30/94; Direct Costs: $297,413.
10. Pilot Study of Troglitazone in Women with Prior Gestational Diabetes. Source: Parke-Davis Pharmaceutical Research. Dates: 10/94 to 1/95; Direct Costs: $148,854 (INVESTIGATOR INITIATED, DESIGNED ).
11. Finland - Unites States Investigation of NIDDM Genetics. Boehnke M. P.I. (T. Buchanan co-investigator). Source: NIH/NHGRI. Dates: 6/1/94-12/31/98.
12. Randomized Trial of Troglitazone in Women with Prior Gestational Diabetes. Source: Parke-Davis Pharmaceutical Research. Project Dates: 7/1/95-12/31/2000. Total Project Direct Costs: $1,859,528 (INVESTIGATOR INITIATED).
13. Troglitazone Atherosclerosis Regression Trial. Source: Parke-Davis Pharmaceutical Research.
Project Dates 1/97-6/2000. Total Project Direct Costs: $2,869,031 (INVESTIGATOR INITIATED).
14. SCOR: Molecular Genetics of Hypertension (PI: Kedes). Project 1: Characterization of Intermediate Phenotypes for Hypertension in Mexican Americans. T. Buchanan, Project Leader. Source: NIH/NHLBI (1P50 HL 55005). Project Dates: 2/1/96-1/31/2001. 5-year Direct Costs: $1,983,258.
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