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- August 28, 2008 |
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"Paediatric Endocrinology"Dr. Tracey Bridger (biography)
English - 2004-08-06 - 59 minutes
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Summary :
A number of genes have been identified that are important in pituitary development, and in which mutations result in hormonal deficiencies. These include Pit1, PROP1 and others. Dr. Bridger discusses guidelines for the use of growth hormone (GH) (1, 2), and causes of mortality in GH recipients (3-6).
Nutritional Vitamin D deficiency is on the rise, and Dr. Bridger presents the results of a recent survey done by the Canadian Paediatric Society on Vitamin D deficiency rickets in Canada. Vitamin D deficiency may also increase the risk of other disorders (7).
Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in type 1 diabetic children and adolescents, and Dr. Bridger presents the new guidelines for DKA management from the European Society for Paediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society (8).
Dr. Bridger ends her presentation with a discussion about childhood obesity in Canada, as well as risk factors for becoming obese (9) and the consequences of childhood obesity.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Pituitary development and genetics
- Growth Hormone: New guidelines, GH and mortality
- Vitamin D deficiency
- Type 1 diabetes: DKA guidelines
- Obesity
Bibliographic references :
1. Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal SM, Silverman L, Speiser P; The Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee.Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee.J Pediatr. 2003 Oct;143(4):415-21.
2. GH Research Society.Consensus Guidelines for the Diagnosis and Treatment of Growth Hormone (GH) Deficiency in Childhood and Adolescence: Summary Statement of the GH Research Societyjcem.2000;85(11):3990-3993
3. Mills JL, Schonberger LB, Wysowski DK, Brown P, Durako SJ, Cox C, Kong F, Fradkin JE.Long-term mortality in the United States cohort of pituitary-derived growth hormone recipients.J Pediatr. 2004 Apr;144(4):430-6.
4. Van Vliet G et al.Sudden death in growth hormone–treated children with Prader-Willi syndrome J Peds.2004;144(1):129.
5. Swerdlow AJ, Higgins CD, Adlard P, Preece MA.Risk of cancer in patients treated with human pituitary growth hormone in the UK, 1959–85: a cohort study The Lancet.2002;360(9329):273-277.
6. Charles A. Sklar, Ann C. Mertens, Pauline Mitby, Glenn Occhiogrosso, Jing Qin, Glenn Heller, Yutaka Yasui and Leslie L. Robison.Risk of Disease Recurrence and Second Neoplasms in Survivors of Childhood Cancer Treated with Growth Hormone: A Report from the Childhood Cancer Survivor Study JCEM.2002;87(7):3136-3141.
7. Michael F Holick.Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosisAmerican Journal of Clinical Nutrition, Vol. 79, No. 3, 362-371, March 2004.
8. European Society for Paediatric Endocrinology, Lawson Wilkins Pediatric Endocrine Society.ESPE/LWPES consensus statement on diabetic ketoacidosis in children and adolescents Archives of Disease in Childhood 2004;89:188-194
9. Agras WS, Hammer LD, McNicholas F, Kraemer HC.Risk factors for childhood overweight: a prospective study from birth to 9.5 years.J Pediatr. 2004 Jul;145(1):20-5.
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