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- May 12, 2008 |
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"Obesity and Early Changes of Endothelial Dysfunction Determined By Pulse Wave Velocity in Female Caucasian South Africans"Dr. Helen Marcoyannopoulou Fojas (biography)
English - 2005-04-16 - 18 minutes
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Summary :
PURPOSE: To show that abnormal time of Pulse Wave Velocity associated with increased Body Mass Index (BMI) is an early indication of atherosclerosis.
METHOD: Pulse Wave Velocity was determined indirectly with the use of infrared sensors which picked up and recorded the left external carotid and left dorsalis pedis arteries simultaneously with a single lead ECG. The time delay between the two pulses was determined. A shorter time of PWV would indicate decreased arterial wall elasticity.
MATERIALS: A group of one hundred and fifteen Caucasian South African females were included. Their ages ranged from 19 to 56 years. Of the total, forty one were lean with a BMI ranging from 18.84 to 24.75; thirty two were overweight with a BMI from 25.08 to 29.97; and, forty two were obese with a BMI from 30.16 to 48.91.
RESULTS: Mean time (sec.) of PWV for each sub-group was:
1.Lean - (BMI - <25) -0.1760;
2.Overweight - (BMI - >25 to 30)-0.163; and,
3.Obese - (BMI - >30) - 0.161.
The difference between overweight and obese subjects is not statistically significant. However, the difference between the lean individuals and the two sub-groups (overweight and obese) combined is significant with a p-value of 0.031.
CONCLUSION: Arterial wall elasticity as determined by Pulse Wave Velocity, is decreased in overweight and obese individuals making them high risks for the development of cardiovascular disease.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
Data from a study of 115 Caucasian South African women on:
- The relationship between arterial wall elasticity and BMI
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