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- July 20, 2008 |
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"Neuropituitary"Dr. Ali Imran (biography)
English - 2004-08-06 - 63 minutes
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Summary :
In this presentation Dr. Imran discusses the clinical scenarios related to various neuroendocrine disorders.
Acromegaly occurs in 3-4 cases per million annually and has various causes. Dr. Imran presents the features and natural history of acromegaly, the associated mortality, diagnostic approach and goals of treatment. Also presented is information about the use of Pegvisomant, a GH receptor antagonist (1).
Dr. Imran then presents the tests for and features of GH deficiency. GH replacement therapy has certain benefits although it remains unclear whether GH treatment improves the mortality associated with this deficiency.
Pituitary apoplexy can be spontaneous or secondary to trauma, skull base fracture, hypertension, diabetes, sickle cell anemia or hypovolemia. Dr. Imran discusses the features and management of this disorder.
The Cushing's syndrome approach starts with knowing which patients to screen. These include patients with abnormal fat deposition in the supraclavicular and temporal areas, proximal muscle weakness, skin thinning, easy bruising and other features discussed in the presentation. Dr. Imran presents the screening tests that may be used, and the differential diagnosis of Cushing's syndrome to distinguish between pituitary-dependent and ectopic disease.
Dr. Imran concludes his presentation with a brief look at the diagnosis of Diabetes Insipidus (2), the water deprivation test and post-surgical DI, followed by a discussion of the management and treatment of prolactinoma in pregnancy.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Apoplexy
- Acromegaly
- Cushing's syndrome approach
- Diabetes Insipidus approach
- Hypogonadism (M&F)
- Non-functioning adenoma approach
- Panhypopit approach
- Prolactinoma & pregnancy
- GH deficiency
Bibliographic references :
1. Peter J. Trainer, M.D., William M. Drake, M.B., Laurence Katznelson, M.D., Pamela U. Freda, M.D., Vivien Herman-Bonert, M.D., A.J. van der Lely, M.D., Eleni V. Dimaraki, M.D., Paul M. Stewart, M.D., Keith E. Friend, M.D., Mary Lee Vance, M.D., G. Michael Besser, M.D., D.Sc., and John A. Scarlett, M.D.Treatment of Acromegaly with the Growth Hormone–Receptor Antagonist PegvisomantNEJM.2000;342:1171-1177.
2. Takako Saito, San-e Ishikawa, Sei Sasaki, Tomoatsu Nakamura, Kumiko Rokkaku, Akio Kawakami, Kazufumi Honda, Fumiaki Marumo and Toshikazu Saito.Urinary Excretion of Aquaporin-2 in the Diagnosis of Central Diabetes InsipidusJCEM.1997;82(6):1823-1827.
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