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- August 28, 2008 |
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CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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| Presentation |
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"Insulin Sensitivity in the Adiponectin Transgenic Mouse"Dr. Terry Combs (biography)
English - 2004-05-14 - 22 minutes
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Summary :
Adiponectin is expressed in adipose tissue, and plasma levels are positively and negatively correlated with insulin sensitivity and BMI, respectively. In this presentation Dr. Combs provides additional information gleaned fom mouse studies on the mechanism of action of this hormone.
Clinical trials have demonstrated that adiponectin is upregulated in tandem with improvement of hyperglycemia in response to the insulin-sensitizing thiazolidinedione drug rosiglitazone. The transgenic adiponectin mouse generated by Dr. Combs' group is a reliable model for inducing circulating adiponectin, in order to be able to better understand its effects. This includes its effects on glucose production versus glucose disposal, as seen from studying different tissues such as muscle, liver and adipose tissue.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
After viewing the presentation the participant will be able to describe the effects of adiponectin on:
- insulin inhibition of endogenous glucose production
- enzymes in the gluconeogenic pathway: AMP-kinase activity, G6Pase and PEPCK expression
Bibliographic references :
Terry P. Combs, Utpal B. Pajvani, Anders H. Berg, Ying Lin, Linda A. Jelicks, Mathieu Laplante, Andrea R. Nawrocki, Michael W. Rajala, Albert. F. Parlow, Laurelle Cheeseboro, Yang-Yang Ding, Robert G. Russell, Dirk Lindemann, Adam Hartley, Glynn R. C. Baker, Silvana Obici, Yves Deshaies, Marian Ludgate, Luciano Rossetti and Philipp E. Scherer A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity Endocrinology 2004; 145(1):367-383
Terry P. Combs, John A. Wagner, Joel Berger, Tom Doebber, Wen-Jun Wang, Bei B. Zhang, Michael Tanen, Anders H Berg, Stephen O’Rahilly, David B. Savage, Krishna Chatterjee, Stuart Weiss, Patrick J. Larson, Keith M. Gottesdiener, Barry J. Gertz, Maureen J. Charron, Philipp E. Scherer and David E. Moller. Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPAR Agonists: A Potential Mechanism of Insulin Sensitization Endocrinology 2004; 143(3):998-1007
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