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- July 4, 2008 |
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| Presentation |
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"Impaired Microvascular Recruitment and Muscle Insulin Resistance"Dr. Michael G. Clark (biography)
English - 2004-05-15 - 53 minutes
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 | (48 slides) |
Summary :
Apart from increasing glucose uptake into muscle, in vivo insulin induces nitric oxide-dependent recruitment of muscle capillaries. In this presentation Dr. Clark speaks about insulin-mediated capillary recruitment, how it is affected by insulin resistant states, and how it affects glucose uptake in muscle.
Copyright © 2004 E-medHosting.com Inc.
Learning objectives :
The participant will learn about:
- Rate-limiting steps in muscle glucose uptake in vivo
- Status of capillary flow in muscle at rest
- Measurement of capillary recruitment
- Effects of insulin and exercise on capillary recruitment
- Insulin resistance
Bibliographic references :
Poulin RA, Steil GM, Moore DM, Ader M, Bergman RN. Dynamics of glucose production and uptake are more closely related to insulin in hindlimb lymph than in thoracic duct lymph. PMID: 8288041 [PubMed - indexed for MEDLINE]
Sjostrand M, Gudbjornsdottir S, Holmang A, Lonn L, Strindberg L, Lonnroth P. Delayed transcapillary transport of insulin to muscle interstitial fluid in obese subjects. Diabetes. 2002 Sep;51(9):2742-8.
Halseth AE, Bracy DP, Wasserman DH. Limitations to basal and insulin-stimulated skeletal muscle glucose uptake in the high-fat-fed rat. Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1064-71.
Rattigan S, Clark MG, Barrett EJ. Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment. PMID: 9287035 [PubMed - indexed for MEDLINE]
Vincent MA, Clerk LH, Lindner JR, Klibanov AL, Clark MG, Rattigan S, Barrett EJ. Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes. 2004 Jun;53(6):1418-23.
Zhang N, Richter A, Suriawinata J, Harbaran S, Altomonte J, Cong L, Zhang H, Song K, Meseck M, Bromberg J, Dong H. Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes. 2004 Apr;53(4):963-70.
Vincent MA, Barrett EJ, Lindner JR, Clark MG, Rattigan S. Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E123-9.
Youd JM, Rattigan S, Clark MG. Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-alpha. Diabetes. 2000 Nov;49(11):1904-9.
S Rattigan, MG Clark, and EJ Barrett Acute vasoconstriction-induced insulin resistance in rat muscle in vivo Diabetes 48: 564-569.
Lucy H. Clerk, Stephen Rattigan, and Michael G. Clark Lipid Infusion Impairs Physiologic Insulin-Mediated Capillary Recruitment and Muscle Glucose Uptake In Vivo Diabetes 51: 1138-1145.
Michelle G. Wallis, Catherine M. Wheatley, Stephen Rattigan, Eugene J. Barrett, Andrew D.H. Clark, and Michael G. Clark Insulin-Mediated Hemodynamic Changes Are Impaired in Muscle of Zucker Obese Rats Diabetes 2002 51: 3492-3498.
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