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   - July 20, 2008
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 Presentation

"Genetics, Environment and a Global Epidemic"

Dr. Salim Yusuf (biography)
English - 2002-10-28 - 31 minutes
(19 slides)
(2 questions)

Summary :
It is not commonly recognized that the majority of cardiovascular disease now occurs in developing countries. While cardiovascular disease rates had increased in western countries between 1950 and 1980, they have come down markedly (by as much as 50%) in many countries, including Canada and the US. By contrast the age-adjusted rates of cardiovascular disease is increasing in most of the developing countries. It is unlikely that this initial increase in cardiovascular disease is due to increasing obesity, which leads to high rates of the metabolic syndrome as well as dyslipidemia. Subsequently, as efforts to control obesity, as well as to decrease tobacco consumption , start to take effect, societies have been able to decrease the rates of cardiovascular disease. This presentation will give an overview of the factors associated with cardiovascular disease globally and suggest the need for societal level interventions to prevent this epidemic.

Learning objectives :
The presentation will outline the rising burden of obesity and diabetes globally and discuss the proposed hypotheses for the dramatic rise in metabolic syndrome.

Bibliographic references :
Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization.

Yusuf S, Reddy S, Ounpuu S, Anand S.

Population Health Research Institute and Division of Cardiology, McMaster University, Hamilton, Ontario, Canada. yusufs@mcmaster.ca

This two-part article provides an overview of the global burden of atherothrombotic cardiovascular disease. Part I initially discusses the epidemiologic transition which has resulted in a decrease in deaths in childhood due to infections, with a concomitant increase in cardiovascular and other chronic diseases; and then provides estimates of the burden of cardiovascular (CV) diseases with specific focus on the developing countries. Next, we summarize key information on risk factors for cardiovascular disease (CVD) and indicate that their importance may have been underestimated. Then, we describe overarching factors influencing variations in CVD by ethnicity and region and the influence of urbanization. Part II of this article describes the burden of CV disease by specific region or ethnic group, the risk factors of importance, and possible strategies for prevention.

Circulation 2001 Nov 27;104(22):2746-53


   


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