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- July 20, 2008 |
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| Presentation |
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"Effects of fatty acids on glucose metabolism and the metabolic syndrome"Dr. Meredith Hawkins (biography)
English - 2005-11-08 - 42 minutes
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 | (25 slides) |
Summary :
In this presentation Dr. Hawkins talks about the role of increased free fatty acids in various clinical manifestations of insulin resistance, including increased glucose production, the lack of its regulation by hyperglycemia, insulin resistance per se and a procoagulant state.
Beginning with the role of increased free fatty acids in increasing glucose production, elevated insulin and glucose levels normally have the effect of suppressing glucose production, however in type 2 diabetic individuals, glucose production is elevated even in the presence of hyperinsulinemia or hyperglycemia. Increased free fatty acids may influence glucose production by a number of mechanisms such as providing more energy for gluconeogenesis, and modulating the activity of liver enzymes involved in the regulation of glucose production.
In 6-hour euglycemic/hyperglycemic pancreatic clamp studies conducted by Dr. Hawkins' group, increasing the plasma FFA levels in nondiabetic subjects resulted in a reduced effectiveness of glucose per se to suppress glucose production, whereas when FFA levels were lowered in type 2 diabetic individuals to levels similar to those of nondiabetic subjects, there was a restoration of the ability of hyperglycemia to suppress glucose production.
Dr. Hawkins shows further data from nondiabetic subjects showing that increased free fatty acid levels induced marked insulin resistance, increased circulating PAI-1 levels, and increased PAI-1 gene expression in whole adipose tissue as well as adipose tissue macrophages.
Copyright © 2006 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
The role of increased free fatty acid levels in the following manifestations of insulin resistance:
- Increased glucose production and its lack of regulation by hyperglycemia
- Reduced insulin action
- Increased PAI-1 circulating levels and gene expression
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