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- July 20, 2008 |
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"Ectopic fat and oxidative stress: common denominators in the 'Metabolic Syndrome' and its vascular sequelae"Dr. Robin Buckingham (biography)
English - 2004-05-14 - 55 minutes
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 | (35 slides) |
 | (42 slides) |
Summary :
In this presentation Dr. Buckingham describes how ectopic fat storage and oxidative stress are implicated in the metabolic syndrome and type 2 diabetes. Excess fat is unstable and pervasive, according to Dr. Buckingham. This fat may radiate out from established storage sites such as visceral depots and into skeletal muscle, liver and the heart. The effects of ectopic deposition of triglycerides in these tissues is described here.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
The participant will learn about:
- Oxidative enzyme activity and lipid concentrations in skeletal muscle in obesity and type 2 diabetes
- Effects of fatty liver in type 2 diabetes
- Importance of fat cell size in the development of type 2 diabetes
- Fat as a source of inflammation
- Epicardial fat: association with metabolic syndrome parameters
- Mechanism underlying endothelial dysfunction in type 2 diabetes
Bibliographic references :
Joseph L. Evans, Ira D. Goldfine, Betty A. Maddux and Gerold M. Grodsky. Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes Endocrine Reviews 2002; 23(5): 599-622.
Tomasz J. Guzik, MD PhD; Shafi Mussa, MA MRCS; Daniela Gastaldi, MD; Jerzy Sadowski, MD PhD; Chandi Ratnatunga, FRCS; Ravi Pillai, FRCS; Keith M. Channon, MD MRCP. Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus Circulation 2002;105:1656.
David E. Kelley, Therese M. McKolanis, Refaat A. F. Hegazi, Lewis H. Kuller, and Satish C. Kalhan. Fatty liver in type 2 diabetes mellitus: relation to regional adiposity, fatty acids, and insulin resistance Am J Physiol Endocrinol Metab 2003; 285: E906-E916.
Tomasz Mazurek, MD*; LiFeng Zhang, PhD*; Andrew Zalewski, MD; John D. Mannion, MD; James T. Diehl, MD; Hwyda Arafat, MD, PhD; Lea Sarov-Blat, PhD; Shawn O’Brien, PhD; Elizabeth A. Keiper, BS; Anthony G. Johnson, MD; Jack Martin, MD; Barry J. Goldstein, MD, PhD; Yi Shi, MD, PhD. Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators Circulation 2003;108:2460.
James B. Meigs, MD, MPH; Frank B. Hu, MD, PhD; Nader Rifai, PhD; JoAnn E. Manson, MD, DrPH. Biomarkers of Endothelial Dysfunction and Risk of Type 2 Diabetes Mellitus JAMA. 2004;291:1978-1986.
Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV, Ravussin E. A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia. 1995 Oct;38(10):1213-7.
Paul M Ridker, MD; Julie E. Buring, ScD; Nancy R. Cook, ScD; Nader Rifai, PhD. C-Reactive Protein, the Metabolic Syndrome, and Risk of Incident Cardiovascular Events An 8-Year Follow-Up of 14 719 Initially Healthy American Women Circulation 2003;107:391.
Hideki Urakawa, Akira Katsuki, Yasuhiro Sumida, Esteban C. Gabazza, Shuichi Murashima, Kohei Morioka, Noriko Maruyama, Nagako Kitagawa, Takashi Tanaka, Yasuko Hori, Kaname Nakatani, Yutaka Yano and Yukihiko Adachi. Oxidative Stress Is Associated with Adiposity and Insulin Resistance in Men The Journal of Clinical Endocrinology & Metabolism 2003; Vol. 88, No. 10 4673-4676.
Ram Weiss et al. Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning Lancet 2003; 362(9388):951-957
C. Weyer, J. E. Foley, C. Bogardus, P.A. Tataranni, R.E. Pratley. Enlarged subcutaneous abdominal adipocyte size, but not obesity itself, predicts Type II diabetes independent of insulin resistance Diabetologia 2000; 43(12):1498-1506.
Haiyan Xu, Glenn T. Barnes, Qing Yang, Guo Tan, Daseng Yang, Chieh J. Chou, Jason Sole, Andrew Nichols, Jeffrey S. Ross, Louis A. Tartaglia and Hong Chen. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance J. Clin. Invest. 112:1821-1830 (2003).
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