 |
|
 |
- May 12, 2008 |
|
|
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.
CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
|
|
|
| Presentation |
|
"Control of Adipocyte Function by Nuclear Receptors of the PPAR and REV-ERBalpha Family"Prof. Bart Staels (biography)
English - 2005-04-14 - 34 minutes
|
 | (26 slides) |
Summary :
Lipid and carbohydrate homeostasis is controlled by integrated systems that allow higher organisms to respond to metabolic changes. Numerous signals reciprocally convey information about body fat status from the periphery to the central nervous system in an attempt to maintain body weight stable throughout life. The role of the adipocyte in energy homeostasis goes beyond its function as a simple energy storage cell. Indeed, adipose tissue not only secretes fatty acids, but is also an active endocrine and paracrine organ that produces proteins and lipid mediators collectively called adipokines. These observations have spurred interest in the identification of the transcriptional and other regulatory pathways controlling adipocyte differentiation. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) (NR1C3) and members of the CCAAT enhancer-binding protein (C/EBP) family are central mediators controlling adipocyte differentiation and function. Rev-erbalpha (NR1D1) is an orphan nuclear receptor encoded on the opposite strand of the thyroid receptor alpha gene. Rev-erbalphaacts as a negative regulator of transcription binding to identical response elements as another orphan nuclear receptor, RORalpha. Rev-erbalpha is highly expressed in adipose tissue, skeletal muscle, heart, liver and brain. Rev-erbalpha expression increases during adipocyte differentiation of 3T3-L1 cells and is induced by PPARgamma activation in both 3T3-L1 cells in vitro and in rat adipose tissue in vivo via a direct repeat (DR2) in the Rev-erbalpha promoter. Ectopic expression of Rev-erbalpha potentiates adipocyte differentiation induced by PPARgamma agonists in 3T3-L1 cells. These observations suggest a role for this nuclear receptor in adipocyte differentiation downstream of PPARgamma.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Rev-erbα- and PPARγ-mediated effects in vivo
- The effects of Rev-erbα deficiency in vivo
|
|
|
|
|
|
| Search our website |
 |
| |
Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes. |
| |
|
|
| Social |
|
| |
Let others know about this presentation.
|
|
|
|
