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- May 10, 2008 |
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"Association of Low Testosterone and Insulin-Like Growth Factor-1 but High C-Reactive Protein with Metabolic Syndrome in Chinese Middle-Aged Men with a Family History of Type 2 Diabetes"Dr. Wing Yee So (biography)
English - 2005-04-14 - 23 minutes
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Summary :
Aim: Age-related decline in testosterone and insulin-like growth factor-1 (IGF-1) may interact with familial disposition to increase the association with metabolic syndrome (MES).
Methods: We compared clinical characteristics and prevalence of fMES using the WHO criteria with modified definitions of obesity for Asians (BMI³25kg/m2) between 179 middle aged men with family history (FH) of diabetes [aged 39.1±8.1 years] and 128 men without FH [aged 43.8±8.5 years].
Results: Men with a FH of diabetes had higher prevalence of MES compared to those without FH of diabetes [39.1% vs 23.4%(p=0.004)]. Among individuals with a FH of diabetes, those with MES were older, had lower serum concentrations of IGF-1, sex hormone binding globulin and total testosterone but higher level of C-reactive protein (hs-CRP) and white blood cell count. Total testosterone, IGF-1 and hs-CRP levels were independently associated with MES explaining 35% of the variance of MES. The prevalence of MES increased with declining tertiles of total testosterone and IGF-1 but increasing tertiles of hs-CRP. After adjustment for age and smoking history, subjects with all three risk factors had a 13-fold increase in association with MES compared to those without hormonal and inflammatory risk factors. In contrasts, the relationship between total testosterone, IGF-1 and hs-CRP with MES was not evident in men without a FH of diabetes, despite having similar BMI, WHR and insulin resistance.
Conclusions: Clustering of a family history of diabetes, hormonal abnormalities and high hs-CRP is associated with metabolic syndrome in Chinese middle-aged men.
Learning objectives :
After viewing this presentation, participants will be able to discuss:
• The incidence of metabolic syndrome in Chinese men with and without a family history of diabetes
• The association of testosterone, IGF-1 and hs-CRP with the metabolic syndrome
• The metabolic profiles of subjects with/without metabolic syndrome, with/without a family history of diabetes.
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