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- May 17, 2008 |
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| Presentation |
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"Antipsychotics and Diabetes"Prof. John Prins (biography)
English - 2007-11-21 - 25 minutes
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Summary :
In this presentation Prof. Prins talks about the relationship between the use of therapies for major psychiatric disorders and the increase in the incidence of metabolic dysfunction.
Different types of studies have suggested a trend toward worsening metabolic dysfunction with antipsychotic therapies (1). An important effect of these therapies is weight gain, and related to the weight gain there may be insulin resistance, impaired beta-cell function, dyslipidemia and hypertension; diabetic ketoacidosis has also been described with atypical antipsychotics although its relationship with weight gain and other metabolic disorders hasn't been established (2). There is evidence too of within-class differences in metabolic effects (3).
Prof. Prins discusses changes in each of the metabolic parameters in relation to treatment as well as how to manage patients who are on atypical antipsychotics.
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Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Metabolic dysfunction in schizophrenia
- Metabolic effects of antipsychotic therapies
- Data to suggest within-class differences in metabolic effects of antipsychotics
- Management of patients taking atypical antipsychotics
Bibliographic references :
1. Holt RIG and Peveler RC Association between antipsychotic drugs and diabetes Diabetes, Obesity and Metabolism 8 (2) , 125–135.
2. Haupt DW, Kane JM.
Metabolic risks and effects of atypical antipsychotic treatment. J Clin Psychiatry. 2007 Oct;68(10):e24.
3. STEPHEN H. SCHULTZ, MD, STEPHEN W. NORTH, MD, mph, and CLEVELAND G. SHIELDS, PhD. Schizophrenia: A Review Am Fam Physician. 2007 Jun 15;75(12):1821-9.
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